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. Author manuscript; available in PMC: 2013 Feb 21.
Published in final edited form as: Vaccine. 2011 Dec 15;30(9):1737–1745. doi: 10.1016/j.vaccine.2011.12.026

Fig. 5. Analyses for prevention of acquisition of a repeated rectal challenge and post infection levels of viral RNA, colorectal CD4 T cells, and Env specific Ab.

Fig. 5

(A) Results of 3 independent challenges using the SIVsmE660-Hirsch2000 stock under the same conditions. YO is year old. (B) Kaplan-Meier survival curves for vaccinated and pooled unvaccinated animals. The exact log-rank test indicates differences in the risk of infection for each of the two vaccine groups and the pooled control group, (C) Post challenge levels of viral RNA in animals that became infected. The day of infection is considered to be one week before virus was first detected in blood. (D) Post challenge levels of rectal CD4 T cells as a percent of total CD3 T cells. Data in (C) and (D) are medians with 25th and 75th percentiles indicated. Data for DDMM-vaccinated animals are in turquoise, those for MMM vaccinated animals in fuchsia, and those for unvaccinated animals in black. The grey box represents the level below which responses are not considered significant.