Fig. 7. Correlations.
Correlation between number of challenges to infection and avidity of the vaccine-elicited Ab for the Env of the SIVE660 challenge in DDMM (A) but not MMM (B) vaccinated animals. Avidity measurements are for Ab collected at 2 weeks after the last immunization. (C) Lack of a correlation with prevention with TRIM5α genotype. r designates a restrictive genotype; m, a genotype that is heterozygous for restrictive (TRIM5α TFP or TRIM5α CYPA) and susceptible (TRIM5αQ) genotypes, and s, a genotype that is homozygous for the susceptible genotype. The MMM group included no animals in the “s” group. DDMM animals are in turquoise, MMM vaccinated animals, in fuchsia; and unvaccinated animals, in black. Animals that did not become infected are plotted at 14 challenges. Data for individual animals can be found in supplementary Table 1.
