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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Neuropharmacology. 2012 Jan 21;62(5-6):2118–2125. doi: 10.1016/j.neuropharm.2012.01.003

Figure 2.

Figure 2

The effects of chronic nicotine and withdrawal from chronic nicotine on contextual fear conditioning. A second set of animals were tested by an independent investigator to examine behavior on the last day of chronic treatment and to replicate withdrawal findings. Chronic nicotine had no effect on contextual fear conditioning but withdrawal deficits in learning were seen on the first 4 days of withdrawal. All time points are separate groups of mice. * = significant difference from saline (n=8). Data are presented as mean and standard error of the mean.