Table 2.
Cerebellum | Hours After Withdrawa1 | ||||||
---|---|---|---|---|---|---|---|
Cytisine Sensitive | 0 | 24 hrs | 48hrs | 72hrs | 96hrs | 120 hrs | 144 hrs |
Saline | 13.80 | 15.59 | 15.17 | 12.95 | 10.49 | 10.84 | 13.48 |
Standard Error | 1.24 | 1.29 | 1.27 | 0.73 | 1.73 | 1.09 | 0.92 |
Nicotine | 21.71 * | 18.29 | 18. 16 | 13.47 | 16.65 * | 14.19 | 15.30 |
Standard Error | 0.94 * | 1.10 | 1.24 | 0.60 | 1.49 * | 1.56 | 0.89 |
| |||||||
Cytisine Resistant | 0 | 24hrs | 48hrs | 72hrs | 96hrs | 120 hrs | 144 hrs |
| |||||||
Saline | 4.09 | 4.89 | 4.72 | 4.14 | 5.24 | 5.50 | 5.50 |
Standard Error | 0.18 | 0.21 | 0.20 | 0.23 | 0.26 | 0.29 | 0.28 |
| |||||||
Nicotine | 4.88 | 4.62 | 5.47 | 4.11 | 5.86 | 5.93 | 5.45 |
Standard Error | 0.33 | 0.47 | 0.31 | 0.13 | 0.53 | 0.31 | 0.26 |
Cortex | Hours After Withdrawa1 | ||||||
---|---|---|---|---|---|---|---|
Cytisine Sensitive | 0 | 24hrs | 48hrs | 72hrs | 96hrs | 120 hrs | 144 hrs |
Saline | 36.26 | 34.81 | 37.03 | 35.35 | 26. 87 | 39.61 | 36.90 |
Standard Error | 3.90 | 4.13 | 6.16 | 4.86 | 3.59 | 4.19 | 2.74 |
Nicotine | 49.17 | 40.78 | 46.34 | 51.85* | 38.82 | 40.93 | 32.45 |
Standard Error | 4.84 | 1.34 | 4.49 | 3,79* | 4.46 | 6.06 | 5.95 |
| |||||||
Cytisine Resistant | 0 | 24hrs | 48hrs | 72hrs | 96 hrs | 120 hrs | 144 hrs |
| |||||||
Saline | 4.15 | 4.43 | 3.87 | 4.16 | 3.86 | 4.15 | 3.77 |
Standard Error | 0.27 | 0.32 | 0.21 | 0.19 | 0.23 | 0.38 | 0.16 |
Nicotine | 5.76 * | 5.13 | 4.99 | 5.65 * | 4.99 | 4.25 | 4.17 |
Standard Error | 0.43 * | 0.47 | 0.50 | 0.73 * | 0.24 | 0.45 | 0.29 |
Indicates significant difference between nicotine and saline. Data presented as mean and standard error of the mean.