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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Invest Dermatol. 2011 Nov 24;132(3 0 1):642–649. doi: 10.1038/jid.2011.377

Table 2.

Mean of highest relative expression1, mean time of highest relative expression, and times of significant elevation (P < 0.05) of cytokines and iNOS in growing feathers collected prior to and throughout the development of vitiligo in SL chickens

Target gene Highest Expression Mean2 Time (weeks)3 Times Elevated4
IFN-gamma 31.82 ± 5.53 1.43 ± 0.43 0, 1, 2, 3
IL-10 56.26 ± 12.42 1.00 ± 0.53 −1, 0, 1, 2, 3
IL-21 56.49 ± 12.82 0.86 ± 0.46 0, 1, 2, 3
IL-1beta 7.47 ± 1.91 1.57 ± 0.43 0, 1, 3
IL-4 2.60 ± 1.01 2.72 ± 0.78 none
IL-6 4.06 ± 1.59 0.43 ± 0.53 0, 1, 2, 3
IL-8 36.64 ± 9.48 1.14 ± 0.58 1
IL-12beta 3.19 ± 0.82 1.14 ± 0.77 0, 2
IL-15 5.70 ± 2.15 2.00 ± 0.84 2
iNOS 7.61 ± 2.52 1.14 ± 0.55 1, 2
1

Relative expression was expressed as fold changes with respect to expression levels in feather samples from three non-vitiliginous SL chickens (calibrator sample).

2

Mean ± SEM of the 7 SL chickens’ highest expression level of each target gene during SLV development.

3

Mean time ± SEM (n = 7) in weeks (with respect to SLV onset; week 0) when highest expression occurred.

4

Time in weeks with respect to SLV onset (week 0) when targets were significantly (P ≤ 0.05) elevated compared to pigmented growing feathers collected from the 7 SLV chickens more than 2 weeks before SLV onset (BV samples). Also see Figure 3.