Skip to main content
. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Invest Dermatol. 2011 Nov 24;132(3 0 1):642–649. doi: 10.1038/jid.2011.377

Table 3.

Comparison between vitiligo in SL chickens (SLV) and in humans

SLV Human vitiligo References
Main target tissue Growing feathers Skin
Phenotype Symptom Depigmentation in growing feathers Depigmentation in the skin
Associated autoimmune disorders Autoimmune thyroiditis, alopecia-like feathering defect Autoimmune thyroiditis and other disorders of immune origin (Erf, 2010; Spritz, 2010)
Onset Early puberty to young adults (6–14 wks of age) Early puberty to young adults (10–30 y of age) (Erf, 2010; Smyth, Jr., 1989)
Severity Erratic to complete Erratic, occasionally complete (Erf, 2010; Smyth, Jr., 1989)
Etiology Multifactorial (genetic, immunologic, metabolic and environmental factors) Multifactorial (genetic, immunologic, metabolic and environmental factors) (Boissy and Nordlund, 2011; Erf, 2010)
Genetics Vitiligo susceptibility genes Multigenic, identification in progress Multigenic, candidate genes identified (Spritz, 2010; Wick et al, 2006)
Intrinsic melanocyte defects Yes Yes (Boissy et al, 1986; 1991)
Immunology Target tissue infiltrating leukocytes Macrophages, CD4, CD8, and B cells Macrophages, CD4 and CD8 cells (Erf et al, 1995; Le Poole et al, 1996)
Melanocyte-specific autoantibodies Yes Yes (Austin et al, 1992; Harning et al, 1991)
Cytokines1 and iNOS in the affected tissue ↑IFN-gamma ↑IFN-gamma (Grimes et al, 2004; Wang, 2001)
↑IL-10 ↑IL-10 (Grimes et al, 2004)
↑IL-6 ↑IL-6 (Moretti et al, 2002; Moretti et al, 2009)
IL-4 no change IL-4 no change (Grimes et al, 2004)
IL-17 low levels of expression ↑IL-17 (Bassiouny and Shaker, 2011)
↑IL-21,
↑IL-1beta,
↑IL-8,
↑IL-12beta,
↑IL-15, and
↑iNOS
Not determined
Metabolism Oxidative stress Yes Yes (Erf et al, 2005; Schallreuter et al, 1999)
Environmental factor Viral association Positive association with live HVT2 vaccination at hatch Possible association with HCV3 and HIV4 (Erf et al, 2001; Seyedalinaghi et al, 2009; Tsuboi et al, 2006)
1

the expression profile of cytokines and iNOS in the growing feather were determined in the current study.

2

herpesvirus of turkey

3

hepatitis C virus

4

human immunodeficiency virus