Table 3.

Risk of (1) death and (2) any complication after surgery for skeletal metastases in 306 patients with prostate cancer

	Simple Cox regression a			Multiple Cox regression b
Endpoint	HR	(95% CI)	p-value	HR	(95% CI)	p-value
Death (1)
Age
> 70 years	1.3	(1.0–1.6)	0.07	1.4	(1.1–1.9)	0.01
< 70 years	Ref.			Ref.
Anatomical location
Femur	1.3	(1.0–1.7)	0.05	1.2	(0.9–1.6)	0.4
Humerus	0.7	(0.4–1.1)	0.09	0.6	(0.4–1.0)	0.05
All other	Ref.			Ref.
Type of fracture
Pathological	1.3	(1.0–1.7)	0.04	1.3	(1.0–1.8)	0.06
Impending	Ref.			Ref.
Metastases
Generalized	2.1	(1.2–3.6)	0.006	2.4	(1.4–4.2)	0.002
Multiple skeletal	2.2	(1.3–3.6)	0.002	2.3	(1.4–3.8)	0.001
Single skeletal	Ref.			Ref.
Any complication(2)
Anatomical location
Pelvis	2.3	(1.3–4.3)	0.007	2.3	(1.2–4.2)	0.01
All other	Ref.			Ref.

^aCrude HR. ^b Adjusted HR.

HR: hazard ratio; CI: confidence interval.