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. Author manuscript; available in PMC: 2013 Feb 8.
Published in final edited form as: Cell Metab. 2012 Feb 8;15(2):171–185. doi: 10.1016/j.cmet.2012.01.004

Figure 4. Caveolin-1 null mice display an altered response the PEPCK inhibition.

Figure 4

Acute response to PEPCK inhibition: 12 week old female cohorts were fasted for 5h at daytime prior to intra-gastric administration of 30mg/kg 3-MPA (n=5 per group). Glucose levels were transiently lowered (A), while lactate (B) and glycerol (C) increased in the caveolin-1 null mice. Chronic response to PEPCK inhibition: Fasting-induced hepatic steatosis, followed by CT in female mice (8 month old; n=5 per group), was aggravated in presence of PEPCK inhibitor (D). Glucose levels were measured at the end of the time course and remained higher in both PBS and 3-MPA treated caveolin-1 null mice (E). (F) Glycerol-induced glucose production measured in PEPCK-inhibited female mice (3 months old; n=4–5 per group) was higher in caveolin-1 nulls indicating that the higher glucose levels in caveolin-1 null mice during fasting is mediated by an increase in glycerol-induced gluconeogenesis. The error bars indicate SEM.