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. Author manuscript; available in PMC: 2013 Feb 8.
Published in final edited form as: Cell Metab. 2012 Feb 8;15(2):171–185. doi: 10.1016/j.cmet.2012.01.004

Figure 5. Caveolin-1 deficiency results in reduced hepatic triglyceride synthesis, increase in reactive oxygen species, elevated adipose tissue FFAs and increased macrophage infiltration.

Figure 5

(A) Intravenous infusion of 3H-triolein in mice fasted for 5h and reveals a reduced hepatic triglyceride synthesis in the liver of caveolin-1 null mice. Note that the 3H count in the organic phase of adipose tissue (BAT and IWAT) was increased in the caveolin-1 null mice. This indicates an increase in triglyceride synthesis rate; (B) and (C): Circulating H2O2 and pyruvate levels in 2 month old mice after 5h of fasting (n=10−12 per group). (D) Adiponectin and pyruvate levels measured in female 4 month old mice were positively correlated. (E) Local FFA levels from gonadal adipose tissue pieces (n=4+4) obtained from 5 month old females. (F) and (G) Gonadal adipose tissue stained for respectively mac2 and perilipin. The error bars indicate SEM.