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. 2002 Sep;161(3):1007–1013. doi: 10.1016/S0002-9440(10)64261-7

Figure 4.

Figure 4.

Methylation pattern representation of the p15 and p16 CpG island-amplified fragments. Black oval, methylated CpG site; white oval, unmethylated CpG site; half black/half white oval, partially methylated CpG site. A: All the 11 CpG sites included in the p16-amplified fragment showed complete methylation in all of the sequenced NHLs and HLs. B1: The 12 CpG sites comprised in the p15-amplified fragment showed complete methylation in NHLs. B2: The p15 methylation pattern was heterogeneous in HL because variation in the state of the CpG sites was observed not only in the same sample but also between cases (each row represents a HL case).