Figure 6.

Treatment of early postnatal mice with the JAK/STAT inhibitor AG490 decreases expression of GFAP and GLAST in the white matter. Mice were treated with AG490 (10 mg/kg, i.p.) from P6 to P11. Western blot analysis was performed on P11 lysates from AG490-treated and control mice. A, Treatment with AG490 decreases GFAP and GLAST expression in the white matter. B, Protein levels are expressed relative to actin loading control. Data are shown ± SD (n = 4–6 animals; *p < 0.05, **p < 0.01 unpaired Student's t test).