FIG. 1.

Fibronectin treatment blocks mechanical allodynia, but not thermal hyperalgesia in dorsal column crush (DCC) rats. (A) Both CS-1 (DCC+CS-1, n=8) and fibronectin (DCC+FN, n=8) treatment resulted in a complete block of mechanical allodynia compared to rats treated with vehicle only (DCC+vehicle, n=10). (B) The hindpaw withdrawal latencies were not significantly influenced by DCC or fibronectin treatment. A thin line was added to indicate the pre-DCC baseline values as compared with later time points to showcase the development of allodynia.