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. 2012 Feb 10;29(3):589–599. doi: 10.1089/neu.2011.2059

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Copyright 2012, Mary Ann Liebert, Inc.

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FIG. 5. — Fibronectin promotes plasticity of serotonin (5-HT) fibers in the dorsal white matter. After dorsal column crush (DCC) and vehicle treatment, 5-HT immunoreactivity was similar to that of controls, with a slight increase observed in the dorsal white matter in both the corticospinal tract (CST, top row; A, B, and C) and the dorsal column (DC, bottom row; E, F, and G), at 1 day (A and E), 14 days (B and F), and 8 months (C and G) after DCC. However, fibronectin treatment induced abundant sprouting of descending 5-HT fibers with numerous intensely-stained fibers apparent in the dorsal white matter (n=3 each group; ^xversus normal rats; *versus vehicle-treated DCC rats). (D) The lesion in the spinal cord caused by DCC is indicated by the dashed line. The boxed areas denote regions selected for quantification of 5-HT immunoreactivity in the CST (L-DC, left dorsal column; R-DC, right dorsal column). (H) A representative 5-HT-immunostaining image taken from the L-DC, R-DC, and CST.