Table 4.

Interaction of SAHA standard ligand and second modified ligand with class II HDAC Homo sapiens.

Ligand	Docking interaction
	HDAC 4	HDAC 5	HDAC 6	HDAC 7	HDAC 9	HDAC 10
SAHA	Zn2+, Asp287, His155, His 195	Zn2+, Asp272, His 140	Zn2+, His32, His33, Tyr204	Zn2+, Asp191, His153, His154	Zn2+, Asp188, His22, His150, His151	Zn2+, Asp226, His95, His96, Phe163, Tyr266
2b	Zn2+, Asp193, Glu117, His155, Pro162, Tyr167	Zn2+, His140	Zn2+, Ala39, Asp71, His32, His33, Gly202	Zn2+, Ala160, Glu115, His153, Phe163, Thr109, Thr111	Zn2+, Asp188, His150, His151, Pro220	Zn2+, Asn103, Asp133, His95, Phe163
2c	Zn2+, Asp193, His155	Zn2+, Asp178, His140	Zn2+, His32, His33, Tyr204	Zn2+, Asp191, Glu115, His153, Thr109, Thr111	Zn2+, Asp188, Gly322, His150, His151	Zn2+, Asp133, His95, His96, Phe163
2d	Zn2+, Asp193, His155, Tyr167	Zn2+ ,Asp178, His140, His141, Glu102	Zn2+, His32, His33, Tyr204	Zn2+, His153, His154, Phe163	Zn2+, Asn217, Asp188, His190	Zn2+, Asn103, Asp133, His95, His96, Tyr266
2e	Zn2+, Asp193, His155	Zn2+, Asp178, His140, Tyr60	Zn2+, Gly99, His32, His33, Tyr204	Zn2+, Asp285, Glu115, Gly326	Zn2+, Asp188, His150, His151, His190, Ser19, Thr20	Zn2+, Asp133, Gln98, His96, Phe163
2f	Zn2+, Asp193, His155, His195	Zn2+, Asp178, His140, Phe209	Zn2+, His32, Thr100	Zn2+, Asp110, Asp285, His153, His154	Zn2+, Asp188, Asp217, Gly322, His150, His151	Zn2+, Asn103, Asp133, His95, His96,

* Bold is the catalytic sites..