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. 2012 Feb 14;3:8. doi: 10.3389/fpsyt.2012.00008

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Copyright © 2012 Loche, Simonetti, Lobina, Carai, Colombo, Castelli, Barone and Cacciaglia.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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Effect of the acute, intragastric administration of low (A), moderate (B), and high doses (C) of GET73 – tested in three independent experiments – on the “alcohol deprivation effect” (ADE) in Sardinian alcohol-preferring (sP) rats. Alcohol (10% v/v, in water) was offered under the standard, homecage two-bottle “alcohol vs water” choice regimen with unlimited access for 24 h/day. Alcohol-deprived rats were deprived of alcohol for 14 consecutive days; alcohol-non-deprived rats had continuous access to alcohol and water. Thirty minutes before representation of the alcohol bottle (which coincided with lights off), both alcohol-deprived and -non-deprived rats were treated acutely with GET73. Alcohol intake was registered 60 min after lights off. Each bar is the mean ± SEM of n = 7–18. *P < 0.05 with respect to alcohol-non-deprived rats receiving 0 mg/kg GET73 (Newman–Keuls test); ^+P< 0.05 with respect to alcohol-deprived rats receiving 0 mg/kg GET73 (Newman–Keuls test).