Table 2.
Effect of the acute, intraperitoneal administration of different doses of GET73 on latency of entry into the dark compartment in training and test sessions in Sprague-Dawley rats exposed to the Passive Avoidance test.
| GET73 (mg/kg) |
||||
|---|---|---|---|---|
| 0 | 5 | 10 | 25 | |
| EXPERIMENT 4a | ||||
| Training session (day 1) | 15.2 ± 4.1 | 10.1 ± 3.5 | 21.6 ± 4.0 | 10.0 ± 3.7 |
| Test session (day 2) | 180.0 ± 0.0 | 180.0 ± 0.0 | 180.0 ± 0.0 | 180.0 ± 0.0 |
| EXPERIMENT 4b | ||||
| Training session (day 1) | 11.5 ± 2.9 | 8.5 ± 1.8 | 7.8 ± 2.0 | 8.4 ± 2.0 |
| Test session (day 2) | 180.0 ± 0.0 | 162.8 ± 17.2 | 180.0 ± 0.0 | 146.4 ± 22.5 |
| EXPERIMENT 4c | ||||
| Training session (day 1) | 12.4 ± 2.7 | 13.9 ± 3.6 | 8.5 ± 2.1 | 6.8 ± 2.0 |
| Test session (day 2) | 146.9 ± 22.1 | 162.1 ± 17.9 | 162.1 ± 17.9 | 164.6 ± 15.4 |
GET73 was administered acutely 30 min before the training session (Experiment 4a), immediately after the training session (Experiment 4b), or 30 min before the test session (Experiment 4c). Each value is the mean ± SEM of n = 9–10.