Table 4.

Effect of the acute, intragastric administration of different doses of GET73 on a series of variables measured in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test.

	GET73 (mg/kg)
	0	5	10	25	50
Number of ECAs	6.3 ± 1.1	7.7 ± 1.1	7.0 ± 0.3	6.0 ± 0.9	8.2 ± 1.7
Total number of SAPs	6.3 ± 1.4	3.8 ± 0.9	4.0 ± 0.9	1.0 ± 0.7*	1.2 ± 0.4**
Number of protected SAPs	5.7 ± 1.2	3.2 ± 0.4	3.8 ± 0.9	1.0 ± 0.7*	1.2 ± 0.4**
Number of unprotected SAPs	0.6 ± 0.4	0.6 ± 0.6	0.2 ± 0.2	0.0 ± 0.0	0.0 ± 0.0
Total number of HDs	8.6 ± 1.3	11.6 ± 2.7	17.0 ± 2.9	15.5 ± 3.8	11.6 ± 1.9
Number of protected HDs	6.9 ± 1.1	4.4 ± 1.0	6.0 ± 1.4	8.0 ± 2.3	5.6 ± 1.7
Number of unprotected HDs	1.7 ± 0.7	7.2 ± 3.0	11.0 ± 3.0**	7.5 ± 1.9*	6.0 ± 0.4**
Number of end-arm explorations in OAs	0.3 ± 0.3	2.2 ± 1.4	4.8 ± 1.7**	5.5 ± 0.3**	5.0 ± 0.8**

CA, closed arm; OA, open arm; ECAs, entries into CAs; SAPs, stretched attend postures; HDs, head dippings.

Stretched attend postures were defined as the rat’s stretching to its full length with the forepaws, keeping the hindpaws in the same place, and then resuming the initial position. Protected SAPs were defined as those SAPs occurring in the CAs. Unprotected SAPs were defined as those SAPs occurring in the OAs. HDs were defined as moving the head below the level of the maze floor. Protected HDs were defined as those HDs occurring in the CAs. Unprotected HDs were defined as those HDs occurring in the OAs. End-arm explorations in OAs were defined as the rat reaching the last 10-cm portion of the open arm.

GET73 was administered acutely 30 min before the EPM test. Exposure to the EPM lasted for 5 min. Entry into a given arm was scored once the rat had all four paws in that arm. Each value is the mean ± SEM of n = 4–7. *P < 0.05 and **P < 0.01 with respect to 0-mg/kg GET73-treated rat group (Kruskal–Wallis and Mann–Whitney test).