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FGF21 induces adipose thermogenic gene expression and browning of WAT. Mice were chronically treated with saline (n = 7) or FGF21 (n = 9) for 72 h. Real-time PCR analysis of thermogenic gene expression is shown from BAT (A), IWAT (B), and PRWAT (C). (D) H&E and UCP1 immunostaining in IWAT. Data are shown ±SEM; saline versus FGF21, (*) P < 0.05.
