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. 2012 Feb 1;26(3):271–281. doi: 10.1101/gad.177857.111

Figure 5.

Figure 5.

PGC-1α is required for the FGF21-mediated induction of thermogenic genes. To assess whether PGC-1α mediates the thermogenic effects of FGF21 in vitro, primary adipocytes sourced from αFKO mice were treated with FGF21 for 48 h. Real-time quantitative PCR analysis is shown from primary brown (A) and inguinal white (B) adipocytes. To test the effects in vivo, αFlox and αFKO mice were treated for 3 d with either saline or FGF21. mRNA expression of PGC-1α target genes is shown from IWAT (C) and BAT (D). Data are shown ±SEM. Saline (n = 8–9) versus FGF21 (n = 11–12), (*) P < 0.05; αFlox versus αFKO, (#) P < 0.05.