Capillary fragmentation linked to Sur1, the target of glibenclamide. A,B: images of the penumbra immunolabeled for laminin showing fragmentation of capillaries in rats administered scrambled oligodeoxynucleotide (SCR) (A), vs. elongated, intact capillaries in rats administered antisense oligodeoxynucleotide directed against Abcc8 (AS), the gene that encodes Sur1 (B). Bar graph: length of capillaries measured with laminin in 3 groups, as indicated; remote sections were from 7 mm proximal to the injury; *, P<0.05; adapted from Simard et al., 2010.