Table 3.
LOD Scores for the DFNA2 Locus Regiona
| Marker Name |
Physical Positionsb |
Genetic Positionsc |
MPT LODd |
2-Point LOD, Recombination Fraction | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0.00 | 0.01 | 0.05 | 0.10 | 0.20 | 0.30 | 0.40 | ||||
| rs213006 | 21,551,187 | 46.050 | 1.25 | 0.34 | 0.34 | 0.33 | 0.32 | 0.26 | 0.18 | 0.10 |
| rs6426746 | 22,501,644 | 47.280 | −∞ | −∞ | 1.20 | 0.53 | 0.27 | 0.06 | 0.02 | 0.03 |
| rs742230 | 25,124,011 | 51.220 | −∞ | −∞ | 0.90 | 0.25 | 0.01 | 0.15 | 0.16 | 0.11 |
| rs6564 | 28,085,562 | 54.000 | 0.05 | 1.60 | 1.56 | 1.39 | 1.17 | 0.72 | 0.28 | 0.01 |
| rs1886651e,f | 29,579,999 | 55.000 | −∞ | −∞ | 0.15 | 0.35 | 0.40 | 0.19 | 0.07 | 0.12 |
| rs555920 | 30,832,451 | 57.011 | 2.91 | −0.09 | 0.03 | 0.13 | 0.21 | 0.21 | 0.13 | 0.04 |
| rs12409103 | 31,747,269 | 59.610 | 3.27 | 0.35 | 0.34 | 0.28 | 0.22 | 0.12 | 0.05 | 0.01 |
| rs760594 | 33,231,390 | 60.510 | 3.34 | 0.47 | 0.46 | 0.41 | 0.35 | 0.23 | 0.11 | 0.03 |
| rs899378 | 34,287,917 | 61.420 | 3.41 | 0.45 | 0.44 | 0.39 | 0.33 | 0.21 | 0.11 | 0.03 |
| rs491603 | 36,304,903 | 64.310 | 3.57 | 1.88 | 1.85 | 1.73 | 1.56 | 1.18 | 0.76 | 0.33 |
| rs6619 | 37,803,283 | 66.140 | 3.56 | 0.45 | 0.44 | 0.39 | 0.33 | 0.21 | 0.11 | 0.03 |
| rs649593 | 37,980,150 | 66.770 | 3.55 | 0.95 | 0.94 | 0.89 | 0.81 | 0.65 | 0.45 | 0.23 |
| rs661316 | 39,403,884 | 69.700 | 3.54 | 1.47 | 1.44 | 1.30 | 1.12 | 0.75 | 0.39 | 0.10 |
| rs209598g | 40,635,418 | 71.570 | 3.52 | 1.51 | 1.48 | 1.36 | 1.22 | 0.91 | 0.60 | 0.28 |
| rs883062g | 42,382,454 | 72.840 | 3.48 | −0.07 | 0.07 | 0.05 | 0.04 | 0.02 | 0.01 | 0.00 |
| rs2782642 | 43,658,908 | 74.310 | 3.43 | −0.04 | 0.04 | 0.03 | 0.02 | 0.01 | 0.00 | 0.00 |
| rs1707302 | 46,373,504 | 75.400 | 3.40 | 0.48 | 0.46 | 0.42 | 0.36 | 0.24 | 0.12 | 0.03 |
| rs926979e | 48,458,022 | 77.800 | 1.68 | −0.12 | 0.11 | 0.06 | 0.02 | 0.01 | 0.02 | 0.01 |
| rs1502856 | 50,644,434 | 78.260 | 1.52 | 0.50 | 0.49 | 0.44 | 0.37 | 0.24 | 0.12 | 0.03 |
| rs1242330f | 53,169,430 | 79.250 | 13.11 | −∞ | 0.90 | 0.28 | 0.08 | 0.04 | 0.04 | 0.01 |
Abbreviations: LOD, logarithm of odds; MPT, multipoint.
All the data are given for theta values of 0.0 to 0.4.
Physical map positions from Build 36 of the human reference sequence.
Genetic map positions from the Rutgers combined linkage-physical map of the human genome, Build 36.
Scores obtained using Allegro1.2c.
These markers flank the haplotype.
These markers delimit the 3-unit support nterval.
The gene KCNQ4 is located between the marker loci rs209598 and rs883062.