(a) dhfr
| Codon | 50 | 51 | 59 | 108 | 164 |
|---|---|---|---|---|---|
| Wild type | Cys (C) | Asn (N) | Cys (C) | Ser (S) | Ile (I) |
| TGT | AAT | TGT | AGC | ATA | |
| AAC | |||||
| Mutant | Arg (R) | Ile (I) | Arg (R) | Asn (N) | Leu (L) |
| CGT | ATT | CGT | AAC | TTA | |
| Thr (T) | |||||
| ACC |
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