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The supraspliceosome model from the article by Sperling et al. [8]. (a) It was stated that pre-mRNA which is not being processed is folded and protected within the native spliceosome. (b) With different staining protocol, it was possible to visualize the RNA strands and loops emanating from the supraspliceosome. These complexes were found to contain hnRNP proteins (personal communication).
