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. Author manuscript; available in PMC: 2012 Feb 14.
Published in final edited form as: Science. 2011 Aug 19;333(6045):1026–1030. doi: 10.1126/science.1206412

Fig. 4.

Fig. 4

Stoichiometric imbalances drive genomic instability. (A) Tenfold serial dilutions of strains harboring YACs on the indicated media. (B) The mutation rate at CAN1. Median and 95% confidence intervals of at least 12 independent cultures are shown. ***P < 0.0005 (Wilcoxon rank-sum test). (C) Fraction of nocodazole-arrested cells displaying Rad52-GFP foci. Means ± SD of three experiments are shown. **P < 0.005 (Student’s t test ). (D) Tenfold serial dilutions of trisomic and corresponding disomic strains on the indicated medium. (E) YAC loss rates in diploid and trisomic strains. Means ± SD of at least 12 independent cultures are shown. (F) YAC loss rates normalized to either haploid or diploid controls. *P < 0.05; **P < 0.005; ***P < 0.0005 (Student’s t test).