Figure 6.

Single cell model for progression of KSHV reactivation and its putative influence on cellular growth. As described in text, Rta expressing PEL cells are depicted as having three fates: complete reactivation (top), expression of a sub-set of DE genes without complete reactivation (middle), and completely abortive reactivation, in which K-Rta might feedback to activate itself (bottom). Modulators of K-Rta function that were discussed in the text are listed in the light blue boxes. Negative regulators (red text) might favor the non-productive reactivation fates, while positive regulators (green text) might favor the productive reactivation fate. DE oncogenes expressed in the top or middle fates, might cooperate with latent proteins to stimulate cell growth (red lines and text). IE, immediate early; DE, delayed early; vDNA repl, viral DNA replication.