Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2013 Jan 1.

Published in final edited form as: Curr Opin Nephrol Hypertens. 2012 Jan;21(1):24–32. doi: 10.1097/MNH.0b013e32834d2ec9

Location of adenosine receptors (ARs) in the kidney mediating cytoprotection. Endothelial and tubular A₁AR activation produces cytoprotection. A_2AARs are found in leukocytes (e.g., neutrophils and lymphocytes) and protect against renal injury by reducing inflammation. Renal tubular and endothelial A_2BARs may also produce renal protection. A₃ARs appear to be expressed in many cell types (e.g., epithelial and endothelial cells) in the kidney. Selective A₃AR antagonist produces renal protection against ischemia and reperfusion injury.

Location of adenosine receptors (ARs) in the kidney mediating cytoprotection. Endothelial and tubular A₁AR activation produces cytoprotection. A_2AARs are found in leukocytes (e.g., neutrophils and lymphocytes) and protect against renal injury by reducing inflammation. Renal tubular and endothelial A_2BARs may also produce renal protection. A₃ARs appear to be expressed in many cell types (e.g., epithelial and endothelial cells) in the kidney. Selective A₃AR antagonist produces renal protection against ischemia and reperfusion injury.