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Factors altering spine density on the apical and basal dendrites of hippocampal CA1 pyramidal neurons. Hormonal status affects dendritic spines on both apical and basal dendrites. In response to learning, spine density changes occur preferentially on basal dendrites. The sensitivity of spines to hormones may provide the opportunity for broad changes in synaptic density and efficacy, whereas the more localized response to learning may reflect more specific responses to experience.
