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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2011 Dec 30;20(3):1213–1221. doi: 10.1016/j.bmc.2011.12.047

Figure 2.

Figure 2

Inhibition of DENV2 NS2B-NS3pro by derivatives of compounds (I-II). The concentrations of the tested compounds and DENV2 NS2B-NS3 protease were 25 μM and 25 nM, respectively. The buffer used contained 200 mM Tris hydrochloride, 6 mM NaCl, and 30% glycerol, pH 9.5. The percent values were calculated from the relative fluorescence units obtained in the presence and absence of tested compound. All assays were performed in triplicate and the average values are shown. The assays were performed as described in the Biochemistry methods section.