Table 5.
Odds ratios (95% confidence interval) for cardiovascular events (coronary heart disease or stroke) in relation to achieved concentrations at 6-month in-trial of both cholesterol and C-reactive protein in subjects allocated to atorvastatin
| Cases/controls | Odds ratios | P-value | |
|---|---|---|---|
| Placebo (ref.) | 88/230 | 1.00 (ref.) | |
| (ASCOT medians) | |||
| LDL ≥2.1 and C-reactive protein ≥1.83 | 27/65 | 1.28 (0.72, 2.26) | 0.40 |
| LDL ≥2.1 and C-reactive protein <1.83 | 17/55 | 0.99 (0.52, 1.88) | 0.98 |
| LDL <2.1 and C-reactive protein ≥1.83 | 11/62 | 0.43 (0.21, 0.88) | 0.02 |
| LDL <2.1 and C-reactive protein <1.83 | 12/76 | 0.49 (0.25, 0.99) | 0.05 |
| (JUPITER cut-offs) | |||
| LDL ≥1.8 and C-reactive protein ≥2 | 30/81 | 1.05 (0.61, 1.81) | 0.85 |
| LDL ≥1.8 and C-reactive protein <2 | 27/94 | 0.93 (0.55, 1.59) | 0.80 |
| LDL <1.8 and C-reactive protein ≥2 | 3/36 | 0.21 (0.06, 0.71) | 0.01 |
| LDL <1.8 and C-reactive protein <2 | 7/47 | 0.42 (0.17, 1.02 | 0.06 |
| (JUPITER cut-offs) | |||
| LDL ≥1.8 and C-reactive protein ≥1 | 46/126 | 1.08 (0.68, 1.72) | 0.75 |
| LDL ≥1.8 and C-reactive protein <1 | 11/49 | 0.76 (0.36, 1.60) | 0.48 |
| LDL <1.8 and C-reactive protein ≥1 | 5/53 | 0.23 (0.08, 0.61) | 0.003 |
| LDL <1.8 and C-reactive protein <1 | 5/30 | 0.53 (0.19, 1.48) | 0.23 |
LDL-cholesterol in mmol/L and C-reactive protein in mg/L. Adjusted for current smoking status, diabetes mellitus, randomized BP treatment (atenolol/amlodipine), left ventricular hypertrophy, baseline SBP, total cholesterol, HDL-cholesterol, BMI, loge-glucose, family history of CHD, creatinine, educational attainment, baseline LDL or total cholesterol, and loge baseline C-reactive protein.