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. Author manuscript; available in PMC: 2012 Feb 14.
Published in final edited form as: Toxicology. 2006 Nov 24;233(1-3):70–78. doi: 10.1016/j.tox.2006.11.061

Table 1.

Enhancement of Oxime Elicited Rates of Reactivation of the SP- Methylphosphonyl Conjugates of Mouse Acetylcholinesterase with Various Mutations.1

kr (mutant) / kr (wild type)
Oxime Mutant graphic file with name nihms-21829-t0005.jpg graphic file with name nihms-21829-t0006.jpg graphic file with name nihms-21829-t0007.jpg
HI-62 F295L 20 12 2.5
F297I 2.9 3.1 1.8
Y337A 18 12 0.18
F295L/Y337A 118 13 0.55
F297I/Y337A 21 7.1 1.8
Y337A/F338A 0.91 0.46 0.13
2-PAM3 F295L 2.1 6.1 0.11
F297I 14 167 0.72
Y337A 6.2 0.22 0.076
F295L/Y337A 2.6 3.7 0.0032
F297I/Y337A 11 1.5 0.49
Y337A/F338A 0.71 2.3 0.043
1

Data computed from Wong et al., 2000 and Kovarik et al., 2004. Structures of SP-cycloheptyl, 3,3-dimethylbutyl and isopropyl methylphosphonate conjugates with AChE are shown.

2

kr (wild type) was 122, 102 and 1330 min−1M−1 for SP-cycloheptyl, 3,3-dimethylbutyl and isopropyl methylphosphonate conjugates, respectively (Kovarik et al., 2004).

3

kr (wild type) was 0.66, 0.18 and 1080 min−1M−1 for SP-cycloheptyl, 3,3-dimethylbutyl and isopropyl methylphosphonate conjugates, respectively (Kovarik et al., 2004).