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. Author manuscript; available in PMC: 2012 Feb 14.
Published in final edited form as: Dev Biol. 2010 Apr 14;343(1-2):28–39. doi: 10.1016/j.ydbio.2010.04.007

Figure 1. Dual functions of Msx1/2 in promoting frontal bone development and suppressing heterotopic bone formation in early migrating cranial mesenchyme.

Figure 1

Skulls of Wnt1-Cre; Msx1cko/cko; Msx2cko/cko mutants at the newborn stage were stained with Alizarin Red to reveal bone. A, wild type; B, Msx1cko/+;Msx2cko/+; C, Msx1cko/+;Msx2cko/cko; D, Msx1cko/cko; Msx2cko/+; E, Msx1cko/cko; Msx2cko/cko. At least five skulls of each genotype were examined. We show representative images. Note increasing size of frontal foramen with decreasing Msx gene dosage up to homozygote-heterozytgote combination (arrows). Note unpatterned, heterotopic bone in area of posterior frontal bone in E (bracket). Images are representative of at least four skulls with similar morphology.