Table 1. In vivo effect of PA1259 and praziquantel.

Treatment	Administration	Schistosomula		Adult
		Mean number of worms ± SD	Worm reduction	Mean number of worms ± SD	Worm reduction
Control		38.6±5.4	_	33.4±5.0	_
PA1259	5×100 mg/kga	26.6±5.3	31%*	21.0±7.0	42%*
PZQ	5×100 mg/kga	30.7±2.4	20%	7.4±7.8	79%*
Control		35.4±5.0	_	33.4±5.0	_
PA1259	4×50 mg/kgb	16.8±7.2	53%*	20.0±5.1	40%*
PZQ	4×50 mg/kgb	21.0±6.0	41%*	4.8±6.5	86%*

Effect on worm recovery of two administration protocols of PA1259 and praziquantel (PZQ) administered to mice harbouring either a 21-day-old schistosomula or 49-day-old adult S. mansoni infection.

^aThe five doses of 100 mg/kg were administered daily during five consecutive days.

^bThe four doses of 50 mg/kg were administered every three hours (overall treatment period: 9 h).

*Significant difference compared to the control group at 5% level (Mann-Whitney U test). SD stands for standard deviation.