Table 2. In vivo effect of PA1647 combined with praziquantel on 21-day-old schistosomula.

		21-day Schistosomula
	Treatment	Mean number of worms ± SD	Worm reduction
1	Control (excipient alone)	43.4±4.9	_
2	4× (PZQ 50 mg/kg)	33.0±1.6	24%
3	4× (PZQ 37.5 mg/kg + PA1647 12.5 mg/kg)	31.0±2.7	29%
4	4× (PZQ 25 mg/kg + PA1647 25 mg/kg)	11.6±3.9	73%*
5	4× (PZQ 12.5 mg/kg + PA1647 37.5 mg/kg)	31.5±3.1	27%
6	4× (PA1647 50 mg/kg)	35.8±4.4	18%

The treatment schedule consisted in four doses of 50 mg/kg (sum of the two drugs) every three hours.

*Significant difference compared to the control group at 5% level (Mann-Whitney U test). SD stands for standard deviation.