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. 2012 Feb 14;7(2):e31384. doi: 10.1371/journal.pone.0031384

Table 2. Losartan reduces tumor invasion in SPARC−/− animals.

Invasion Incidence
Group n =  Total
SPARC+/+ 10 8 (80%)
SPARC+/+ LOS 8 8 (100%)
SPARC−/− 8 8 (100%)
SPARC−/− LOS 8 4 (50%)

Animals bearing orthotopic Pan02 tumors were treated with losartan as described in the methods. Local invasion was defined as tumor growth into adjacent organs with attachment to the primary tumor as determined by necropsy. Invasion incidence was defined as the number of animals in each group with signs of local invasion.