Skip to main content
. 2012 Feb 14;7(2):e31433. doi: 10.1371/journal.pone.0031433

Figure 6. Current and voltage recordings in IHCs from adult Tc1 mice.

Figure 6

A and B, Membrane currents recorded from adult (P25) control and Tc1 apical coil IHCs. Currents were elicited by depolarizing voltage steps in 10 mV nominal increments from −124 mV to the various test potentials shown by some of the traces (holding potential −84 mV). C, Average steady-state current-voltage (I–V) curves obtained from control (P25–P26, n = 7) and Tc1 (P25–P26, n = 5) adult IHCs. D, Average total K+ current (I K,f+I K,s) and isolated I K,f and I K,s measured at the membrane potential of −25 mV. E, Size of I K,n in control and Tc1 mutant IHCs. F, Voltage responses under current clamp from control and Tc1 adult IHCs (P25). Current steps were applied between −100 pA and +900 pA, starting from the resting potential, and for clarity only a few responses are shown. G, non-linear behaviour of the peak voltage responses of IHCs, obtained from the protocol described in panel F. In this and the following Figure, values are shown as mean ± SEM. Recordings are at body temperature.