Table 1. Comparison of genotype distribution of MMP polymorphisms between cancer metastasis positive and negative subjects.

Gene	Cancer type	Country	Ethnicity	Metastasis(+)				Metastasis(−)
				N	AA	AB	BB	N	AA	AB	BB
MMP1 (−1607) 1G/2G
Cao 2005	head/neck	China	Asian	67	27a		40	29	14a		15
Hashimoto 2004	head/neck	Japan	Asian	43	20a		23	86	40a		46
Kondo 2005	head/neck	Japan/Taiwan	Asian	40	6		34b	43	4		39b
Nasr 2007	head/neck	Tunisia	European	118	5	37	76	56	8	26	22
O-charoenrat 2006	head/neck	Thailand	Asian	181	75a		106	119	76a		43
Shimizu 2008	head/neck	Japan	Asian	19	9a		10	50	23a		27
Kouhkan 2008	colorectal	Iran	European	69	31a		38	81	60a		21
Ghilardi 2001	colorectal	Italy	European	17	6a		11	43	31a		12
Woo 2006	colorectal	Korea	Asian	79	2	23	54	106	5	31	70
Jin 2005	gastric	China	Asian	46	2	16	28	48	7	16	25
Matsumura 2004	gastric	Japan	Asian	89	11	42	36	126	15	46	65
Hughes 2007	breast	London	European	52	12	20	20	88	26	43	19
Przybylowska2006	breast	Poland	European	141	33	57	51	129	44	58	27
Fang 2005	NSCLCc	China	Asian	123	13	41	69	74	8	24	42
Fong 2004	chondrosarcoma	Taiwan	Asian	14	6	8	0	53	12	26	15
Jin 2005	ESCCd	China	Asian	59	6	24	29	72	12	29	31
Lai 2005	cervical	Taiwan	Asian	51	12	22	17	89	8	38	43
Albayrak 2007	prostate	Turkey	European	10	3		7b	45	7		38b
MMP2 (−1306) C/T
Cotignola 2007	melanoma	USA	European	129	86	39	4	866	543	281	42
O-charoenrat 2006	head/neck	Thailand	Asian	152	140		12b	87	66		21b
Lei2007	breast	Sweden	European	230	121	86	23	559	317	203	39
Wu2007	gastric	Taiwan	Asian	93	83	7	3	118	88	26	4
MMP3 (−1171) 5A/6A
Hughes 2007	breast	London	European	50	16	29	5	85	23	44	18
Ghilardi 2002	breast	Italy	European	40	15		25b	46	9		37b
Krippl 2004	breast	Austria	European	216	59	103	54	259	43	146	70
Fang 2005	NSCLCc	China	Asian	123	7	41	75	73	0	17	56
Cotignola 2008	melanoma	USA	European	129	21	69	39	853	148	428	277
Tu 2007	head/neck	Taiwan	Asian	59	12a		47	91	20a		71
Zhang 2004	ESCCd	China	Asian	59	1	26	32	72	0	20	52
Zhang 2004	GCAe	China	Asian	46	2	11	33	48	1	12	35
Smolarz 2003	ovarian	Poland	European	61	17	24	20	57	20	22	15
MMP7 (−181) A/G
Hughes 2007	breast	London	European	49	17	20	12	81	30	39	12
Zhang 2005	ESCCd	China	Asian	68	61		7b	87	74		13b
Zhang 2005	GCAe	China	Asian	46	36		10b	63	56		7b
Zhang 2005	NSCLCc	China	Asian	123	101		22b	74	60		14b
Wu 2011	cervical	China	Asian	39	17	14	8	178	96	70	12
MMP9 (−1562) C/T
Nasr 2007	head/neck	Tunisia	European	118	96	20	2	56	43	12	1
Woo 2006	colorectal	Korea	Asian	79	67	11	1	106	88	17	1
Xing 2007	colorectal	China	Asian	46	29		17b	87	71		16b
Hughes 2007	breast	London	European	43	35		8b	76	74		2b
Przybylowska2006	breast	Poland	European	141	83	56	2	129	90	38	1
Lei 2007	breast	Sweden	European	230	164	61	5	555	392	143	20
Wang 2005	NSCLCc	China	Asian	123	89		34b	74	59		15b
Matsumura 2005	gastric	Japan	Asian	63	44	16	3	114	89	22	3
Awakura 2006	renal	Japan	Asian	154	106		48b	25	20		5b
Park 2011	colorectal	Korea	Asian	132	107	24	1	201	163	37	1

^arepresents the number of AA+AB genotype,

^brepresents the number of BB+AB genotype (A represents the major allele, B represents the minor allele),

^cNSCLC represents non-small cell lung carcinoma,

^dESCC represents esophageal squamous cell carcinoma.

^eGCA represents gastric cardiac adenocarcinoma.