Table 3. Multiple regression analysis between clinical co-variables and TLR4-299 genotype* (dependent variable).
Co-variable | Adjusted OR [95%CI] | p value |
Gestational age (wk) | 1.12 [0.77 to 1.63] | 0.56 |
Birth weight (g) | 1.00 [1.00 to 1.00] | 0.78 |
Gender (male or female) | 0.95 [0.36 to 2.49] | 0.92 |
Ethnicity, (Caucasian or not) | 1.05 [0.39 to 2.81] | 0.93 |
Recruitment Centre (A or B) | 0.50 [0.19 to 1.32] | 0.16 |
BPD (none, mild, moderate or severe) | 2.15 [1.17 to 3.97] | 0.014 |
Results are shown for combined heterozygous/rare homozygous genotypes in binary regression. Significance was also comparable using all three genotypes (Asp/Asp, Asp/Gly and Gly/Gly) in regression models using BPD (pā=ā0.016) as the dependent variable.