Table 2. Polymorphism and somatic mutation frequency of microsatellite repeats in miRNA genes.
| CRC cell lines | Colorectal primary tumors | |||||||
| miRNA gene | LBL (%) | Polymorphism | MSS (%) | MSI (%) | P value | MSS (%) | MSI (%) | P value |
| MNR | ||||||||
| hsa-mir-1302-7 | 1/33 (3%)a | yes | 0/13 (0%) | 0/14 (0%)b | NS | 0/24 (0%) | 1/36 (2.8%)b | NS |
| hsa-mir-511 | 3/40 (7.5%)a | yes | 0/13 (0%) | 0/14 (0%)b | NS | 0/23 (0%) | 0/36 (0%)b | NS |
| hsa-mir-543 | 6/35 (17.1%)a | yes | 0/13 (0%) | 1/14 (7%)b | NS | 0/25 (0%) | 2/39 (5%)b | NS |
| hsa-mir-548f-3 | 0/36 (0%) | no | 0/13 (0%) | 0/14 (0%) | NS | 0/23 (0%) | 0/36 (0%) | NS |
| hsa-mir-548f-5 | 0/38 (0%) | no | 0/13 (0%) | 0/14 (0%) | NS | 0/24 (0%) | 1/40 (2.5%) | NS |
| hsa-mir-548u | 0/32 (0%) | no | 0/13 (0%) | 0/12 (0%) | NS | 0/23 (0%) | 0/39 (0%) | NS |
| hsa-mir-328 | 0/34 (0%) | no | 0/12 (0%) | 0/14 (0%) | NS | 0/22 (0%) | 0/40 (0%) | NS |
| hsa-mir-1225 | 0/37 (0%) | no | 0/13 (0%) | 0/13 (0%) | NS | 1/22 (4,6%) | 0/33 (0%) | NS |
| hsa-mir-4271 | 0/33 (0%) | no | 0/10 (0%) | 0/13 (0%) | NS | 0/23 (0%) | 1/38 (2.6%) | NS |
| hsa-mir-92b | 0/38 (0%) | no | 0/13 (0%) | 0/14 (0%) | NS | 0/24 (0%) | 0/40 (0%) | NS |
| hsa-mir-152 | 0/40 (0%) | no | 0/13 (0%) | 0/14 (0%) | NS | 0/20 (0%) | 0/37 (0%) | NS |
| hsa-mir-296 | 0/36 (0%) | no | 0/13 (0%) | 0/14 (0%) | NS | 0/24 (0%) | 0/38 (0%) | NS |
| hsa-mir-1249 | 0/23 (0%) | no | 1/13 (7.7%) | 0/13 (0%) | NS | 0/24 (0%) | 2/39 (5%) | NS |
| hsa-mir-320c-1 | 0/38 (0%) | no | 0/13 (0%) | 0/14 (0%) | NS | 0/23 (0%) | 1/38 (2.6%) | NS |
| hsa-mir-525 | 0/38 (0%) | no | 0/13 (0%) | 2/14 (14.3%) | NS | 0/21 (0%) | 0/33 (0%) | NS |
| hsa-mir-320b-2 | 0/37 (0%) | no | 0/13 (0%) | 1/14 (7.1%) | NS | 0/24 (0%) | 3/40 (7.5%) | NS |
| hsa-mir-644 | 0/40 (0%) | no | 0/12 (0%) | 6/14 (42.9%) | 0.03 | 0/23 (0%) | 8/39 (20.5%) | 0.053 |
| hsa-mir-4329 | 0/40 (0%) | no | 2/12 (16.7%) | 0/13 (0%) | NS | 0/22 (0%) | 6/38 (15.8%) | NS |
| hsa-mir-1273c | 0/32 (0%) | no | 0/13 (0%) | 9/11 (82%) | <0.0001 | 0/25 (0%) | 33/39 (84.6%) | <0.0001 |
| hsa-mir-567 | 0/39 (0%) | no | 0/12 (0%) | 14/14 (100%) | <0.0001 | 2/25 (8%) | 31/39 (79.5%) | <0.0001 |
| hsa-mir-1303 | 20/39 (51%)a | yes | 0/13 (0%) | 12/14 (85.7%)b | <0.0001 | 0/23 (0%) | 33/40 (82.5%)b | <0.0001 |
| DNR | ||||||||
| hsa-mir-1277 | 0/40 (0%) | no | 0/13 (0%) | 0/14 (0%) | NS | 0/25 (0%) | 1/41 (2.4%) | NS |
| hsa-mir-620 | 32/40 (80%)a | yes | 0/13 (0%) | 1/14 (7%)b | NS | 0/21 (0%) | 1/38 (2.6%)b | NS |
| hsa-mir-558 | 35/40 (87.5%)a | yes | 0/12 (0%) | 4/13 (30.8%)b | 0.095 | 0/24 (0%) | 12/38 (31.6%)b | 0.006 |