FIG. 7.

Bcl-3 deficiency in hematopoietic cells exacerbates type 1 diabetes. A: Bone marrow chimeric B6 mice were generated by injecting wild-type or Bcl3^−/− bone marrow cells into wild-type or Bcl3^−/− mice (n = 12) as described in research design and methods. Eight weeks later, mice were injected with low-dose streptozotocin to induce diabetes. Mice were monitored for the development of diabetes for 45 days. Results are representative of two independent experiments. B: A quantity of 1.5 × 10⁷ splenic T-cells isolated from wild-type or Bcl3^−/− NOD mice were injected into NOD.scid mice (n = 6–7) through the tail vein. Mice were monitored for the development of spontaneous diabetes for 11 weeks. Results are representative of two independent experiments.