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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Neurobiol Aging. 2010 Aug 5;33(4):670–680. doi: 10.1016/j.neurobiolaging.2010.06.003

Table 3.

Negative association of homocysteine, fractional anisotropy, and mediation by dietary condition.

Fiber tract Coordinates (x, y, z) Peakt-value Cluster size
(voxels)
Homocysteine associations
R Pontocerebellar fibers 0,6,7 3.68 1448
Homocysteine*Condition
R Occipito-splenial Fibers 10, −12, 20 4.23 5784
 Splenium of CC 10, −2, 18 4.14
 Splenium of CC 0, 2, 17 3.73

L = Left hemisphere; R = Right hemisphere. CC = Corp us Callosum. The interaction tested where CR monkeys showed more fractional anisotropy relative to controls per unit increase in Hcy, suggesting a protective effect. The voxel and cluster thresholds were p < .005 (uncorrected) and p < .05 (corrected) respectively.