Table 4.
Positive association of homocysteine, mean diffusivity, and mediation by dietary condition.
| Region | Coordinates (x, y, z) | Peakt-value | Cluster size (voxels) |
|---|---|---|---|
| Homocysteine associations | |||
| L Medial Anterior Lobe of Cerebellum | −6, −5, 8 | 4.49 | 2243 |
| R Medial Anterior Lobe of Cerebellum | 6, −4, 8 | 4.20 | |
| R Dorsal Prefrontal Cortex | 9, 40, 24 | 3.93 | 1363 |
| R Ventral Prefrontal Cortex | 17, 38, 18 | 3.53 | |
| Homocysteine*Condition | |||
| R Anterior Cingulate Cortex | 2, 36, 18 | 3.85 | 4398 |
| L Medial Prefrontal Cortex | −2,44,14 | 3.11 | |
| R Dorsal Prefrontal Cortex | 3, 44, 22 | 2.96 | |
| R Primary Visual Cortex | 19, −17, 29 | 3.83 | 1322 |
| R Primary Visual Cortex | 14, −22, 27 | 3.60 | |
L = Left hemisphere; R = Right hemisphere. The interaction tested where CR monkeys showed less mean diffusivity relative to controls per unit increase in Hcy, suggesting a protective effect. The voxel and cluster thresholds were p < .005 (uncorrected) and p < .05 (corrected) respectively.