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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Eur J Neurosci. 2012 Jan 25;35(3-4):562–571. doi: 10.1111/j.1460-9568.2011.07972.x

Figure 3. p66-KO mice showed less axonal damage than WT mice following EAE induction.

Figure 3

Figure 3

A) Lower power view of plastic-embedded toluidine-blue stained thoracic spinal cord sections from representative naïve (left), p66-KO (middle), and WT (right) mice 36 days following EAE induction. Red indicates circled areas of damage. B) Higher power view of sections. Note the greater preservation of axonal integrity in the p66-KO mice compared to WT mice. C) p66-KO mice showed a significant 42% reduction in ventrolateral white matter damage compared to WT mice. D) Lower power view of plastic-embedded toluidine-blue stained optic nerve sections from representative naïve (left), p66-KO (middle), and WT (right) mice 36 days following EAE induction. Red indicates circled areas of damage. E) Higher power view of sections. Note the greater preservation of axonal integrity in the p66-KO mice compared to WT mice. F) p66-KO mice showed a significant 38% reduction in optic nerve damage compared to WT mice.