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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Scand J Immunol. 2012 Mar;75(3):301–304. doi: 10.1111/j.1365-3083.2011.02668.x

Figure 2. Effect of Smad 3 inhibitor (SIS 3) and ALK5 inhibitor (SB 431542) on MTB induced uPAR expression in MN.

Figure 2

MN were prepared and received SIS3 (1 and 5μM) or SB431542 (1 and 5 μM) for 1 hr. Then wells received MTB H37Rvlysate (L) (A) or PPD (B) at 10 μg/ml. After 24 hrs cell lysates were prepared, RNA extracted and assessed for uPAR mRNA. Fold inuction of uPAR (that induced by MTB H37RvL or PPD over that induced in medium alone) is shown. Means ± SEM of 12 experiments is shown.