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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Invest Dermatol. 2012 Jan 26;132(3 0 2):763–775. doi: 10.1038/jid.2011.450

Figure 2. Introduction to Epidermolysis Bullosa Simplex.

Figure 2

Figure 2

A) Schematic representation of skin tissue (left) and detailed view of the bottom portion of the epidermis (right), highlighting the cytoplasmic network of keratin IFs (light green) attached to hemidesmosome cell-ECM (green) and desmosome cell-cell (magenta) contacts in basal keratinocytes. Arrows depict the plane of tissue rupture seen in the “simplex”, “junctional”, and “dystrophic” forms of EB. B) Example of trauma-induced bullous skin lesions (arrows) in the feet of a 2-month old child diagnosed with EBS. Picture kindly provided by Dr. Bernard Cohen (Johns Hopkins School of Medicine; see http://dermatlas.med.jhmi.edu). Adapted from (Coulombe et al., 2009).