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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Nanomedicine. 2011 Sep 9;8(5):731–739. doi: 10.1016/j.nano.2011.08.014

Table 1.

Load, transport and effects of ICAM-1-targeted nanocarriers for lysosomal delivery in cell culture.

Non- loaded ASM α-Gal GAA
Enzyme coating efficiency (%) N/A 80 77 86
Enzyme molecule per NC (50:50 mass) N/A 230 530 278
Anti-ICAM molecule per NC (50:50 mass) 250 135 138 123

Binding (NCs per cell) 165 160 70 80
% Internalization (1 h) 80 70 67 80
% Lysosomal transport (3 h) 75 70 70 65
% Lysosomal storage degradation (5 h) N/A 98 70 75
Enhanced degradation (anti-ICAM/enzyme NCs: free enzyme) N/A 2 2.5 3

N/A = not applicable. Data are mean values from this work and 22,21,23,24.