Table 3.
Odds ratios (99% confidence intervals) for a Mental Scale < 55 and a Mental Scale between 55 and 69 (when Gross Motor Function Classification System < 1) compared to a Mental Scale of 70 or more associated with the highest quartile of the distribution of the protein listed on the left (within gestational age category and day blood was obtained), and adjusted for gestational age. Bold indicates odds ratios significantly > 1 (p < 0.01).
| Mental Scale < 55* (n/N =94/856) | Mental Scale 55-69* (n/N =93/856) | |||||
|---|---|---|---|---|---|---|
| Day 1 | Day 7 | Day 14 | Day 1 | Day 7 | Day 14 | |
| Cytokines and their receptors | ||||||
| IL-1β | 1.0 (0.5, 1.8) | 0.9 (0.5, 1.8) | 1.8 (0.9, 3.3) | 1.0 (0.5, 1.8) | 0.8 (0.4, 1.5) | 1.2 (0.6, 2.3) |
| IL-6 | 1.2 (0.6, 2.4) | 1.8 (1.00, 3.4) | 2.8 (1.5, 5.2) | 1.0 (0.5, 1.9) | 1.3 (0.7, 2.5) | 1.0 (0.5, 2.0) |
| IL-6R | 1.0 (0.5, 1.9) | 1.0 (0.5, 1.9) | 1.0 (0.5, 2.0) | 1.3 (0.7, 2.5) | 0.6 (0.3, 1.3) | 0.8 (0.4, 1.5) |
| TNF-α | 1.5 (0.8, 2.7) | 1.9 (0.98, 3.3) | 2.2 (1.2, 4.2) | 1.0 (0.5, 1.9) | 1.5 (0.8, 2.8) | 1.2 (0.6, 2.3) |
| TNF-R1 | 0.9 (0.5, 1.8) | 1.3 (0.7, 2.4) | 2.1 (1.1, 4.0) | 0.7 (0.4, 1.5) | 0.8 (0.4, 1.7) | 1.1 (0.5, 2.3) |
| TNF-R2 | 1.2 (0.6, 2.4) | 1.8 (0.97, 3.3) | 2.3 (1.2, 4.3) | 1.6 (0.9, 3.0) | 1.2 (0.6, 2.3) | 1.5 (0.8, 3.0) |
| Chemokines | ||||||
| IL-8 (CXCL8) | 1.5 (0.8, 2.9) | 1.8 (0.98, 3.4) | 2.8 (1.5, 5.3) | 1.2 (0.6, 2.3) | 1.1 (0.6, 2.3) | 1.4 (0.7, 2.9) |
| MCP-1 (CCL2) | 1.0 (0.5, 1.9) | 1.1 (0.6, 2.2) | 1.5 (0.8, 3.0) | 0.8 (0.4, 1.7) | 0.9 (0.4, 1.8) | 0.8 (0.4, 1.7) |
| MCP-4 (CCL13) | 0.5 (0.2, 1.1) | 1.0 (0.5, 1.9) | 1.3 (0.7, 2.5) | 0.6 (0.3, 1.2) | 0.8 (0.4, 1.7) | 0.9 (0.5, 1.8) |
| MIP-1β (CCL4) | 1.0 (0.5, 2.0) | 2.2 (1.2, 4.0) | 2.0 (1.1, 3.8) | 1.1 (0.6, 2.1) | 1.8 (0.9, 3.4) | 1.3 (0.6, 2.5) |
| RANTES (CCL5) | 0.9 (0.5, 1.9) | 1.2 (0.6, 2.3) | 0.9 (0.5, 1.8) | 1.1 (0.6, 2.2) | 0.6 (0.3, 1.3) | 0.4 (0.2, 1.02) |
| I-TAC ( CXCL11) | 0.6 (0.3, 1.2) | 1.1 (0.6, 2.1) | 1.4 (0.7, 2.8) | 0.6 (0.3, 1.3) | 0.5 (0.2, 1.1) | 0.7 (0.4, 1.6) |
| Adhesion molecules | ||||||
| ICAM-1 (CD54) | 1.3 (0.7, 2.5) | 2.2 (1.2, 4.0) | 2.2 (1.2, 4.3) | 1.1 (0.6, 2.2) | 1.1 (0.5, 2.2) | 1.2 (0.6, 2.5) |
| ICAM-3 (CD50) | 0.6 (0.3, 1.3) | 1.1 (0.6, 2.0) | 2.0 (1.1, 3.8) | 0.9 (0.5, 1.8) | 0.8 (0.4, 1.7) | 0.8 (0.4, 1.7) |
| VCAM-1 (CD106) | 1.2 (0.6, 2.2) | 1.7 (0.9, 3.1) | 1.7 (0.9, 3.2) | 1.4 (0.7, 2.6) | 0.9 (0.4, 1.7) | 0.9 (0.4, 1.8) |
| E-SEL (CD62E) | 1.5 (0.8, 2.7) | 1.6 (0.9, 3.0) | 2.5 (1.3, 4.8) | 1.1 (0.6, 2.1) | 1.4 (0.7, 2.7) | 1.3 (0.7, 2.5) |
| Matrix metalloproteinases (MMPs) | ||||||
| MMP-1 | 0.9 (0.4, 1.7) | 1.0 (0.5, 1.9) | 0.7 (0.3, 1.4) | 0.6 (0.3, 1.1) | 0.9 (0.5, 1.8) | 0.9 (0.4, 1.8) |
| MMP-9 | 0.6 (0.3, 1.3) | 0.9 (0.5, 1.7) | 1.4 (0.7, 2.7) | 0.8 (0.5, 1.5) | 1.1 (0.6, 2.1) | 0.8 (0.4, 1.7) |
| Other indicators of inflammation | ||||||
| CRP | 1.2 (0.6, 2.4) | 3.0 (1.6, 5.5) | 2.2 (1.2, 4.2) | 0.7 (0.3, 1.4) | 1.5 (0.7, 2.7) | 1.2 (0.6, 2.4) |
| SAA | 1.4 (0.8, 2.7) | 2.0 (1.1, 3.7) | 2.4 (1.3, 4.6) | 1.2 (0.6, 2.3) | 1.3 (0.6, 2.5) | 1.0 (0.5, 2.1) |
| MPO | 0.7 (0.3, 1.4) | 1.5 (0.8, 2.7) | 2.0 (1.1, 3.7) | 1.0 (0.5, 1.8) | 0.7 (0.3, 1.5) | 0.8 (0.4, 1.6) |
| Growth factors, their receptors, and binding proteins | ||||||
| VEGF | 0.7 (0.4, 1.4) | 1.4 (0.8, 2.6) | 1.1 (0.6, 2.1) | 0.8 (0.4, 1.6) | 0.7 (0.3, 1.4) | 0.5 (0.2, 1.1) |
| VEGF-R1 | 1.1 (0.6, 2.1) | 0.9 (0.5, 1.8) | 1.5 (0.8, 2.8) | 1.0 (0.5, 1.9) | 0.9 (0.5, 1.8) | 1.1 (0.6, 2.1) |
| VEGF-R2 | 1.3 (0.7, 2.5) | 1.7 (0.9, 3.1) | 2.0 (1.1, 3.8) | 1.4 (0.7, 2.5) | 1.0 (0.5, 2.0) | 1.2 (0.6, 2.4) |
| IGFBP-1 | 1.7 (0.9, 3.1) | 1.8 (0.96, 3.3) | 1.5 (0.8, 2.8) | 1.1 (0.6, 2.1) | 1.0 (0.5, 2.1) | 0.9 (0.4, 1.8) |
when Gross Motor Function Classification System < 1
Abbreviations: IL-1β : Interleukin-1β; IL-6 : Interleukin-6 ; IL-6R: interleukin-6 receptor; TNF-α: Tumor Necrosis Factor- α; TNF-R1: Tumor Necrosis Factor-alpha receptor 1; TNF-R2: tumor necrosis factor-alpha-receptor-2; IL-8 : Interleukin-8 ; MCP-1: monocyte chemotactic protein-1 (CCL2); MCP-4 : monocyte chemoattractant protein-4 (CCL13) ; MIP-1β: Macrophage Inflammatory Protein-1 beta) (CCL4); RANTES: regulated upon activation, normal T-cell expressed and (presumably) secreted; I-TAC : Interferon-inducible T cell Alpha-Chemoattractant ; ICAM-1: intercellular adhesion molecule-1; ICAM-3: Intercellular adhesion molecule-3 (CD54); VCAM-1: vascular cell adhesion molecule-1 (CD106); E-SEL1: E-selectin (CD62E); MMP-1: Matrix MetalloProteinase-1; MMP-9: matrix metalloproteinase-9; CRP: C-Reactive Protein; SAA: serum amyloid A; MPO: myeloperoxidase; VEGF: Vascular Endothelial Growth Factor; VEGF-R1: Vascular Endothelial Growth Factor-Receptor 1; VEGF-R2: vascular endothelial growth factor-receptor-2; IGFBP-1: Insulin Growth Factor Binding Protein-1