Table V.

Odds ratio (and 95% confidence interval) of the outcome listed at the top of each column among children who had a concentration in the top quartile (for gestational age and day specimen was obtained) of the protein(s) listed on the left on 1 day or 2 or more days relative to that of children who did not have an elevated concentration of the same protein(s). The multinominal regression models compare children whose scores were < 55 and those whose scores were between 55 and 69 to children whose scores were ≥ 70, adjusting for gestational age (23-24, 25-26, 27 weeks). The sample consisted of children who had proteins measured on 2 separate days. The results for Mental Scale and Motor Scale 55-69 are shown in Supplemental Table 3. Bold indicates odds ratios significantly > 1 (p < 0.01).

	Mental Scale < 55* (n/N =91/805)		Motor Scale < 55 (n/N =136/881)
	1 day only	≥ 2 days	1 day only	≥ 2 days
Cytokines and their receptors
IL-1β	1.1 (0.6, 1.8)	1.5 (0.8, 2.6)	1.2 (0.8, 1.9)	1.5 (0.9, 2.4)
IL-6	1.5 (0.9, 2.6)	3.2 (1.8, 5.7)	1.5 (0.98, 2.3)	2.3 (1.4, 3.8)
IL-6R	0.9 (0.5, 1.5)	1.1 (0.6, 1.8)	0.6 (0.4, 1.01)	0.7 (0.4, 1.1)
TNF-α	2.1 (1.2, 3.6)	2.7 (1.5, 4.7)	1.2 (0.8, 1.8)	1.6 (1.01, 2.6)
TNF-R1	1.8 (1.1, 3.0)	1.4 (0.8, 2.7)	1.4 (0.9, 2.1)	1.3 (0.8, 2.2)
TNF-R2	1.6 (0.9, 2.6)	2.2 (1.3, 3.9)	1.2 (0.8, 1.9)	1.3 (0.8, 2.1)
Chemokines
IL-8	1.6 (0.9, 2.7)	3.5 (2.0, 6.2)	1.6 (1.05, 2.5)	2.1 (1.3, 3.5)
MCP-1	1.1 (0.7, 1.8)	1.4 (0.8, 2.5)	1.4 (0.9, 2.1)	1.8 (1.1, 2.9)
MCP-4	0.7 (0.4, 1.2)	0.8 (0.5, 1.5)	1.2 (0.8, 1.8)	0.8 (0.5, 1.3)
MIP-1β	1.5 (0.9, 2.6)	2.5 (1.4, 4.2)	1.2 (0.8, 1.9)	1.2 (0.7, 1.9)
RANTES	0.9 (0.5, 1.5)	1.2 (0.7, 2.1)	0.9 (0.6, 1.3)	0.6 (0.4, 1.1)
I-TAC	1.2 (0.7, 1.9)	1.0 (0.5, 1.8)	0.8 (0.5, 1.3)	0.8 (0.5, 1.2)
Adhesion molecules
ICAM-1	1.4 (0.8, 2.3)	2.5 (1.5, 4.3)	1.1 (0.7, 1.7)	1.8 (1.1, 2.9)
ICAM-3	1.2 (0.7, 2.0)	1.4 (0.8, 2.4)	0.7 (0.5, 1.2)	0.9 (0.5, 1.4)
VCAM-1	1.3 (0.8, 2.3)	1.9 (1.1, 3.3)	1.0 (0.6, 1.5)	0.8 (0.5, 1.3)
E-SEL	1.5 (0.9, 2.6)	2.4 (1.4, 4.1)	0.9 (0.6, 1.4)	1.2 (0.7, 1.9)
Matrix metalloproteinases (MMPs)
MMP-1	0.8 (0.5, 1.5)	0.9 (0.5, 1.5)	0.4 (0.2, 0.8)	0.6 (0.4, 1.03)
MMP-9	1.1 (0.7, 1.8)	0.8 (0.5, 1.6)	0.8 (0.5, 1.2)	0.8 (0.5, 1.4)
Other indicators of inflammation
CRP	1.7 (0.98, 2.8)	3.3 (1.9, 5.7)	1.6 (1.01, 2.4)	2.2 (1.3, 3.5)
SAA	1.3 (0.7, 2.2)	3.3 (1.9, 5.7)	1.4 (0.9, 2.1)	2.2 (1.4, 3.7)
MPO	1.9 (1.2, 3.2)	1.5 (0.8, 2.7)	1.1 (0.7, 1.8)	1.7 (1.1, 2.6)
Growth factors, their receptors, and binding proteins
VEGF	1.2 (0.7, 2.0)	1.1 (0.7, 1.9)	1.1 (0.7, 1.8)	0.7 (0.5, 1.2)
VEGF-R1	1.4 (0.9, 2.4)	1.2 (0.7, 2.2)	1.5 (0.98, 2.3)	1.1 (0.7, 1.8)
VEGF-R2	1.9 (1.1, 3.3)	2.1 (1.2, 3.6)	1.3 (0.8, 1.9)	1.0 (0.6, 1.6)
IGFBP-1	1.1 (0.6, 1.8)	2.2 (1.3, 4.0)	1.1 (0.7, 1.7)	1.6 (0.96, 2.7)

^*when Gross Motor Function Classification System < 1

Abbreviations: IL-1β : Interleukin-1β; IL-6 : Interleukin-6 ; IL-6R: interleukin-6 receptor; TNF-α: Tumor Necrosis Factor- α; TNF-R1: Tumor Necrosis Factor-alpha receptor 1; TNF-R2: tumor necrosis factor-alpha-receptor-2; IL-8 : Interleukin-8 ; MCP-1: monocyte chemotactic protein-1 (CCL2); MCP-4 : monocyte chemoattractant protein-4 (CCL13) ; MIP-1β: Macrophage Inflammatory Protein-1 beta) (CCL4); RANTES: regulated upon activation, normal T-cell expressed and (presumably) secreted; I-TAC : Interferon-inducible T cell Alpha-Chemoattractant ; ICAM-1: intercellular adhesion molecule-1; ICAM-3: Intercellular adhesion molecule-3 (CD54); VCAM-1: vascular cell adhesion molecule-1 (CD106); E-SEL1: E-selectin (CD62E); MMP-1: Matrix MetalloProteinase-1; MMP-9: matrix metalloproteinase-9; CRP: C-Reactive Protein; SAA: serum amyloid A; MPO: myeloperoxidase; VEGF: Vascular Endothelial Growth Factor; VEGF-R1: Vascular Endothelial Growth Factor-Receptor 1; VEGF-R2: vascular endothelial growth factor-receptor-2; IGFBP-1: Insulin Growth Factor Binding Protein-1