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. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: Inflamm Res. 2012 Jan 17;61(2):161–169. doi: 10.1007/s00011-012-0436-8

Eighteen hours following i.t. administration of PL to JHT (a) and MyD88−/− (c) mice and their respective wild-type controls, lungs were examined for histopathology. Shown are representative (n=3) hematoxalin and eosin stained lung sections (100× magnification) revealing the presence of an intact pulmonary inflammatory reaction in JHT mice (a) compared to similarly stained sections from PL-challenged wild-type mice (b). By contrast, histopathological abnormalities are markedly attenuated in MyD88−/− (c) vs (d) wild-type control mice. Solid arrows indicate peribronchial inflammation and stippled arrow indicates perivascular inflammation..

Eighteen hours following i.t. administration of PL to JHT (a) and MyD88−/− (c) mice and their respective wild-type controls, lungs were examined for histopathology. Shown are representative (n=3) hematoxalin and eosin stained lung sections (100× magnification) revealing the presence of an intact pulmonary inflammatory reaction in JHT mice (a) compared to similarly stained sections from PL-challenged wild-type mice (b). By contrast, histopathological abnormalities are markedly attenuated in MyD88−/− (c) vs (d) wild-type control mice. Solid arrows indicate peribronchial inflammation and stippled arrow indicates perivascular inflammation..