Table 3.
Associations between hypothalamic-pituitary-adrenal (HPA) axis and obesity measures using multiple regression
| Serum cortisol | Serum cortisol | Urine free cortisol | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Area under the curve (AUCg) | Net response (AUCi) | Log10 excretion rate (nmol/h) | ||||||||||
| β | B | SE (B) | p | β | B | SE (B) | p | β | B | SE (B) | p | |
| Dependent variable | ||||||||||||
| BMIa | −.103 | −.049 | .028 | .09 | −.076 | −.062 | .048 | .20 | .181 | 3.544 | 1.237 | .005 |
| BMI-Zb | −.174 | −.014 | .005 | .004 | −.144 | −.019 | .008 | .02 | .178 | .560 | .205 | .007 |
| Percent body fatc | −.046 | −.027 | .038 | .48 | −.045 | −.045 | .065 | .49 | .109 | 2.597 | 1.658 | .12 |
| Fat distributiond,e | −.146 | −.003 | .001 | .02 | −.114 | −.004 | .002 | .07 | .146 | .110 | .050 | .03 |
Abbreviations: BMI=body mass index; SES=socioeconomic status; DXA=dual energy X-ray absorptiometry;
Model adjusted for age, race, Tanner stage, and SES.;
Model adjusted for race, Tanner stage, and SES.;
Model adjusted for age, race, and SES.;
Model adjusted for Tanner stage and SES.;
Fat distribution=fat mass in upper/lower body regions (DXA).