A. Mean absolute neutrophil counts (ANC) in patients with DS-ALL (black) and NDS-ALL (gray). B. Mean absolute monocyte counts (AMC) in patients with DS-ALL (black) and NDS-ALL (gray). Asterisks indicate time-points at which ANC and AMC significantly differed between groups (p < 0.05). C. The number of toxicities per 1000 follow-up days is shown for patients with DS-ALL (black) versus NDS-ALL (gray). Overall toxicities are shown, as well as the specific categories of microbiologically documented infections, cellulitis, and mucositis. Asterisks indicate significant differences between groups (p < 0.01). DS, Down syndrome; ALL, acute lymphoblastic leukemia; NDS, non-Down syndrome.